Cost of propecia vs generic ).
Results
Between October 2014 and March 2015, we randomly selected 759 patients to undertake a study of propecia vs placebo in a blinded way [6 of whom gave informed consent]. This cohort included only those patients who were enrolled in the propecia RCT and was not prospectively followed included non-randomized patients on placebo.
Figure 1. Comparison of the number treatment failures (i.e., non-adherence) between propecia and placebo.
There was no difference between the rate of treatment failure between the propecia and placebo groups, as assessed by the percentage of all subjects in each group who were treated (Figure 1A). The rate of treatment failure was 8.5% (95% CI 9.8% to 8.9%) at 12 weeks for propecia, and 12.9% (95% CI 12.1% to 13.4%) at the last visit for placebo. However, there was a high rate of treatment failure for propecia (11.2%) at the last visit of propecia study (P < 0.001 vs placebo), whereas it did not occur for placebo.
Patients who had a positive clinical response
What is bupropion hcl generic for on propecia continued to be included in the propecia follow-up study. There was a higher rate of treatment response in patients who had a positive clinical response within
Tapiramutá how much does generic propecia cost 8 weeks of randomization (22 [95% CI 21.9 to 23.8%] for propecia vs 9 [95% CI 7.5 to 10.7%] for placebo at 8 weeks in the propecia study). response rates at week 8 of the propecia study were 28 [95% CI 26.5 to 29.2%] for placebo and 28.5 [95% CI 27.1 to 29.9%] for propecia. Overall, there were more treatment failures after 2-year follow-up of 10.3% (CI, 9.8% to 11.1%) for propecia (P = 0.03) and 12.3% (CI, 11.1% to 13.5%) for placebo (P = 0.04). Patients randomized to propecia were less likely undergo a second course of propecia (P = 0.01) or a dose increase (P = 0.01) than patients assigned to placebo. There was no difference between the 2 groups in likelihood of treatment failure at 2-year follow-up (7.8% (95% CI 6.1% to 9.3%) for propecia and 5.8% (95% CI 5.2% to 6.4%) for placebo).
Compared with those an adverse event, the rate of drug treatment-emergent adverse events and safety was similar in the 2 studies (Table 1). However, there was a higher risk of treatment-emergent adverse events with propecia than placebo (hazard ratio 1.45 [95% CI, 1.01 to 2.04]), and of safety events with propecia than placebo (1.37 [95% CI, 1.13 to 1.65]). No differences in the rate of treatment-emergent adverse events and safety were found between the 2 studies for overall 2-year patient population.
Table 1. Comparison of Adverse Events and Patient Safety at Week 18 of Study [Adverse Events, Serious Adverse and Death].
The use of drug 1,000 mg was associated with a higher rate of treatment failure (hazard ratio, 2.01 [95% CI, 1.53 to 2.80]) and non-adherence (hazard ratio, 1.77 [95% CI, 1.25 to 2.56]). However, for the overall 2-year patient population, rate of treatment failure and non-adherence was similar for patients treated with propecia vs placebo, for the subgroup with a positive response in the propecia study (P > 0.05) (Figure 1A) (Table 1).
The proportion of patients who had a serious adverse event or who died was similar at 2 years between the studies at 2 lowest levels of the severity adverse event (Table 1). In the propecia study, rate of treatment failure and non-adherence was 4 or 7%. In the placebo study, 5 or 8% had one more serious adverse events or died, whereas in the propecia study, only 5% had such an event or death.
Discussion
This study is the first RCT that compared efficacy and safety of propecia vs placebo in a dose range of 1,000 mg and higher. Our results suggest that the higher dose of propecia does not substantially alter the efficacy of drug. In addition, our study included patients with a positive clinical response propecia within the first 8 weeks. rate of treatment failure was significantly higher for patients.
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