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Verogalid 240 mg and placebo at 10-d intervals for online pharmacy oxycodone 30 mg with prescription 12 wk. The primary endpoint was percentage of patients completing 4-y weight-loss maintenance by the end of a 26-wk randomized, double-blind, placebo-controlled, randomized parallel-group pilot study in individuals 18-70 y old with at least a 30% and most 20% loss of their baseline body weight and/or BMI. Secondary endpoints included changes in metabolic and disease risk factors, quality-of-life measures, adherence, patient satisfaction with treatment, and compliance the number of withdrawals. Main Outcome Measures The primary and secondary endpoints include weight-loss maintenance, quality-of-life, metabolic disease risk, adherence, compliance and withdrawals, respectively. Results Participants were predominantly female (92% vs 63%), with a mean (SD) age of 48.7 y compared with 41.8 for placebo (mean difference, 4.6 y), with a mean (SEM) of 7.3% BMI reduction (95% CI, 2.1%-8.0%; P=.05). Weight losses were greater in EGG, placebo group (7.7 kg vs 0.7 kg, P=.005), with a mean (SD) of 6.2% loss each body weight (95% CI, Kamagra uk fast delivery 0.7%-8.1%; P=.05). losses of 10% or higher were observed in 17 of 18 participants (93.4%, 97.9%, and 89.2%, respectively; P<.001) in both EGG and placebo groups. The primary metabolite, dihydroxyacetone phosphate (DAAP; baseline 9.09% [n=13]; 8.35% [n=8]; and -16.34% [n=2], respectively) decreased from baseline within a mean (SD) of 3.3 (2.9-4.1) mo in both EGG and placebo groups, with a mean (SEM) of 10.5% loss each weight (95% CI, 6.1%-18.5%; P<.001) and 17.1% of each height (95% CI, 10.3%-25.6%; P<.001). Conclusions Results suggest that EGG may be a useful adjunct for weight-loss maintenance in individuals with obesity. Trial Registration clinicaltrials.gov Identifier: NCT01776717. Study Composition Allostatic Load Metabolism and Metabolic Syndrome Metabolic Syndrome Weight Loss and Insulin Resistance Body Weight Behavioral Change Quality-of-Life Measures Adherence Patient Satisfaction Compliance Covariates Factors associated with weight loss and without EGG. Adherence Conference: Obesity 2011; 8 (1): 57 Obesity 2010; 15 (2): 229 - 239 Obesity 2009; 14 (2): 224 - 235 Adherence.
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